Vicky Persinger/Christopher Plys (Chaska, MN) won 8-5 over Madison Bear/Andrew Stopera (Chaska, MN) in the Final of the USA Curling Mixed Doubles National Championship, held May 19 - 23, 2021 at the Wausau Curling Club in Wausau, United States. To advance to the championship game, Persinger/Plys won 8-5 over Aileen Geving/Luc Violette (Duluth, MN) in the semifinals of the 2021 USA Curling Mixed Doubles National Championship in Wausau, Wisconsin, United States;
 
Persinger/Plys finished 4-1 in the 0-team qualifying round. . In their opening game, Persinger/Plys defeated Audrey Foote/Blake Hagberg (Whitesboro, NY) 12-2, then went on to lose 8-7 against Anne O'Hara/Coleman Thurston (Fairbanks, AK). Persinger/Plys responded with a 8-1 win over Rebecca Rodgers/Daniel Casper (Leydon, MA). Persinger/Plys won 7-5 against Christine McMakin/Riley Fenson (Chaska, MN), then won 8-4 against Jenna Burchesky/Ben Richardson (Walpole, MA) in their final qualifying round match.
 
Persinger/Plys ranks th overall on the Year-to-Date rankings with points earned so far this season.